In:
FEBS Letters, Wiley, Vol. 348, No. 1 ( 1994-07-04), p. 80-88
Abstract:
Transcription of the human c‐ erbB ‐2‐proto‐oncogene starts mainly at two sites, nucleotide positions + 1 and −69. The present studies have identified an initiator‐like element that specifies the position of transcription initiation at position −69. This initiator‐like element contains six GGA repeats and is located just downstream from the transcription start site between positions −68 and −45. In addition, both in vitro and in vivo studies indicated that transcription initiation at position +1 is specified by a TATA box 25 bp upstream from the transcription startpoint. Thus, initiation at two sites in the c‐ erbB ‐2 promoter is controlled independently by the initiator‐like element and the TATA box.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(94)00578-8
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
1460391-3
SSG:
12
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