In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 118, No. 3 ( 1988-07), p. 444-448
Abstract:
Abstract. Endemic goitre and cretinism are still a public health problem in China. An epidemiological survey showed that about 5% of the inhabitants in Daxin village, Henan province, had goitre or cretinism after an iodized salt prevention programme had been carried out for two decades. The main food for the inhabitants of this area has an iodine content 〈 30 nmol/kg and the water for cooking and drinking has an iodine concentration between 7–12 nmol/l. We studied thyroid function in subjects of this village. There were 42 with grade 0 goitre (males 29, females 13), 42 grade I (males 23, females 19), 27 grade II (males 9, females 18), 31 grade III (males 14, females 17) and 34 cretinism patients (males 30, females 4) diagnosed and classified according to WHO criteria. Serum T 4 , free T 4 , T 3 , free T 3 , T 3 uptake, TSH and thyroglobulin were measured in these subjects. The patients with goitre or cretinism had significantly decreased serum free T 4 and increased serum T 3 and free T 3 levels compared with those of controls. Thyroid size was positively correlated with age and serum thyroglobulin concentrations. Serum thyroglobulin was significantly increased even in the grade 0 goitre subjects. The percentages of subjects with serum free T 4 〈 12 nmol/l, T 3 〉 2.5 nmol/l, free T 3 〉 5.2 pmol/l, TSH 〉 3.5 mU/l, T 3 /T 4 ratio 〉 0.03 and free T 3 /free T 4 ratio 〉 0.36 were significantly higher among goitre and cretinism patients than among controls. The data suggest that there is partial compensation for a marginal deficiency of iodine in the inhabitants of this village.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.1180444
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1988
detail.hit.zdb_id:
1485160-X
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