In:
Science, American Association for the Advancement of Science (AAAS), Vol. 264, No. 5167 ( 1994-06-24), p. 1921-1924
Abstract:
The mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-α and especially by IFN-γ was impaired in cells from mice with a null mutation in the IRF-1 gene (IRF-1 -/- mice). The IRF-1 -/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs. The absence of IRF-1 did not clearly affect replication of two other types of viruses. Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.8009222
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
1994
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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