In:
The EMBO Journal, EMBO, Vol. 42, No. 19 ( 2023-10-04)
Abstract:
image The exchange of histones and their variants within nucleosomes plays a crucial role in modulating the epigenome and gene expression. This study shows that ubiquitin‐dependent histone H2B exchange and degradation are crucial in determining C. elegans diapause by regulating the transcriptional activity of DAF‐16/FoxO. Histone H2B undergoes global exchange and degradation during development and starvation in C. elegans . The components of the ubiquitin‐proteasome system (UPS), including ubiquitin/UBQ‐1, E1/UBA‐1, E2/UBC‐20, and E3/HECD‐1, regulate H2B exchange and degradation by ubiquitinating H2B at lysine 31. Disruption of H2B exchange and degradation enhances the binding of DAF‐16/FoxO to chromatin, resulting in aberrant activation or suppression of target genes, and ultimately leading to larval death. Ubiquitin‐dependent histone H2B exchange and degradation are conserved in mammalian cells.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022113328
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
Permalink