In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 168, No. 6 ( 2013-06), p. 805-810
Abstract:
Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. Methods A total of 100 euthyroid men (free triiodothyronine (fT 3 ), 4.77±1.21 pg/ml; free thyroxine (fT 4 ), 1.38±0.21 ng/dl; and TSH, 2.09±0.91 μIU/ml) were enrolled in this cross-sectional study. We measured accumulated regional fat using 64-slice multi-detector computed tomography. Multiple linear regression analysis was used to determine whether accumulated fat in each region was associated with clinical parameters after adjusting for age. Results FT 3 was inversely correlated with BMI ( r =−0.232, P =0.029) and LDL cholesterol level ( r =−0.277, P =0.019). FT 4 was inversely correlated with waist circumference ( r =−0.350, P =0.008) and BMI ( r =−0.355, P 〈 0.001). In multiple linear regression analysis, fT 3 and fT 4 levels were significantly associated with pericardial fat volume (fT 3 : B =−0.079, 95% CI −0.142 to −0.017, P =0.013; fT 4 : B =−0.411, 95% CI −0.780 to −0.042, P =0.030) in euthyroid men, independent of age. FT 3 level was inversely associated with intramuscular fat area ( B =−0.059, 95% CI −0.106 to −0.011, P =0.016) and hepatic fat quantity ( B =−0.237, 95% CI −0.441 to −0.033, P =0.024) in euthyroid men, independent of age. Conclusions In euthyroid men, low levels of fT 3 and fT 4 were significantly associated with increased pericardial fat volume and BMI.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2013
detail.hit.zdb_id:
1485160-X
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