In:
FEBS Letters, Wiley, Vol. 473, No. 1 ( 2000-05-04), p. 19-23
Abstract:
The MA‐01 antigen, a thermolabile 210 kDa microtubule‐interacting protein, is present in P19 embryonal carcinoma cells on microtubular structures as well as in cytosol. After aggregation of the cells and subsequent incubation with all‐ trans ‐retinoic acid (RA), the level of MA‐01 expression increased approximately 10 times during 15 days. The increase started after 2 days of incubation with RA and preceded the appearance of neuron‐specific tubulin βIII, MAP2C and neurofilaments. Such elevated expression of MA‐01 antigen was not detected in P19 cells treated with dimethylsulfoxide. These data indicate that enhanced expression of MA‐01 antigen is one of the earliest events occurring in P19 cells during neuronal differentiation.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(00)01488-5
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
212746-5
detail.hit.zdb_id:
1460391-3
SSG:
12
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