In:
FEBS Letters, Wiley, Vol. 353, No. 1 ( 1994-10-10), p. 67-70
Abstract:
Rabphilin‐3A is a putative target protein for Rab 3A, a small GTP‐binding protein particularly implicated in neurotransmitter release. Rabphilin‐3A interacts more preferentially with GTP‐ Rab 3A than with GDP‐ Rab 3A. Moreover, Rabphilin‐3A shows a weak activity to stimulate the GTPase activity of Rab 3A and a strong activity to inhibit the Rab 3A GTPase‐activating protein (GAP)‐stimulated GTPase activity of Rab 3A. Here, we show that Rabphilin‐3A has another activity to stimulate the GDP/GTP exchange reaction of Rab 3A. Rabphifin‐3A may keep Rab 3A continuously in the GTP‐bound form by converting again GDP‐ Rab 3A, which may be converted from GTP‐ Rab 3A by Rab 3A GAP, to GTP‐ Rab 3A, until the function of Rab 3A is accomplished.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(94)01015-3
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
1460391-3
SSG:
12
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