In:
FEBS Letters, Wiley, Vol. 301, No. 2 ( 1992-04-20), p. 190-194
Kurzfassung:
Treatment of rat mesangial cells with interleukin‐1β(IL‐1β) and forskolin induced, in a synergistic fashion,the expression of group II phospholipase A 2 (PLA 2 ) mRNA, with subsequent increased synthesis and secretion of PLA 2 . In contrast, interleukin‐6 did not increase PLA 2 mRNA levels of PLA 2 activity. Transforming growth factor (TGF) β 1 , TGFβ 2 and TGFβ 3 equipotently attenuated the IL‐1β‐ and forskolin‐induced elevation of PLA 2 mRNA, as well as PLA 2 synthesis and secretion. The glucocorticoid dexamethasone only partially suppressed the IL‐1β‐ and forskolin‐induced elevation of PLA 2 mRNA, but totally inhibited PLA 2 synthesis and secretion.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(92)81245-H
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1992
ZDB Id:
1460391-3
SSG:
12
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