In:
Human Heredity, S. Karger AG, Vol. 87, No. 3-4 ( 2022), p. 96-101
Kurzfassung:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The role of neuraminidases in cardiovascular disease has recently gained increasing attention. However, the association between neuraminidase gene polymorphisms and heart failure (HF) has not yet been investigated. 〈 b 〉 〈 i 〉 Methods and Results: 〈 /i 〉 〈 /b 〉 Genotyping of nine single-nucleotide polymorphisms (SNPs) in the NEU2/NEU3/NEU4 genes was performed in 610 HF patients and 600 healthy controls from the Southwest Han Chinese population using TaqMan SNP Genotyping Assay. Individuals carrying the A allele of rs11545301 had decreased risk of HF (additive model: OR = 0.704, 95% CI = 0.511–0.97; 〈 i 〉 p 〈 /i 〉 = 0.032). However, the C allele of rs2293763 increased the risk of HF in the recessive model (OR = 1.486, 95% CI = 1.095–2.012; 〈 i 〉 p 〈 /i 〉 = 0.011). Rs2233384, rs2233394, and rs2293763 were significantly associated with the mortality risk of HF in the dominant model, both with and without adjustment for conventional risk factors (HR = 0.686, 95% CI = 0.52–0.906, 〈 i 〉 p 〈 /i 〉 = 0.008 for rs2233384, HR = 1.357, 95% CI = 1.035–1.78, 〈 i 〉 p 〈 /i 〉 = 0.027 for rs2233384, and HR = 0.76, 95% CI = 0.592–0.975, 〈 i 〉 p 〈 /i 〉 = 0.031 for rs2293763). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our findings demonstrated the association between a series of variants in NEU2/NEU4 genes and the risk or prognosis of HF in the Han Chinese population. These data suggested an important role of NEU2 and NEU4 in the pathogenesis of HF.
Materialart:
Online-Ressource
ISSN:
0001-5652
,
1423-0062
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2022
ZDB Id:
1482710-4
SSG:
12
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