In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 97, No. 26 ( 2000-12-19), p. 14257-14262
Abstract:
The complete genomic sequence of the archaeon Thermoplasma
volcanium , possessing optimum growth temperature (OGT) of
60°C, is reported. By systematically comparing this genomic sequence with the other known genomic sequences of archaea, all possessing
higher OGT, a number of strong correlations have been identified between characteristics of genomic organization and the OGT. With
increasing OGT, in the genomic DNA, frequency of clustering purines and pyrimidines into separate dinucleotides rises (e.g., by often forming
AA and TT, whereas avoiding TA and AT). Proteins coded in a genome are divided into two distinct subpopulations possessing isoelectric points
in different ranges (i.e., acidic and basic), and with increasing OGT the size of the basic subpopulation becomes larger. At the metabolic
level, genes coding for enzymes mediating pathways for synthesizing some coenzymes, such as heme, start missing. These findings provide
insights into the design of individual genomic components, as well as principles for coordinating changes in these designs for the adaptation
to new environments.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.97.26.14257
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2000
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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