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  • OceanRep  (3)
  • 1
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    Scalarane sesterterpenes from the Egyptian Red Sea sponge Phyllospongia lamellosa (2015)
    Elsevier
    In:  Tetrahedron, 71 (4). pp. 577-583.
    Details
    Publication Date: 2020-05-13
    Description: Biology and HRESIMS-guided screening of the dichloromethane fraction of the marine sponge Phyllospongia lamellosa collected from the Red Sea resulted in the isolation and characterization of five new scalarane sesterterpenes; phyllospongins AeE (1e5), in addition to four known derivatives, 12a-acetoxy- 20,24-dimethyl-25-norscalar-16-en-24-one (6), 12a-acetoxy-13b,18b-cyclobutan-20,24-dimethyl-24- oxoscalar-16-en-25b-ol (7), 12a-acetoxy-24,25-epoxy-24-hydroxy-20,24-dimethylscalarane (8), and scalardysin-A (9) that were previously isolated from Carteriospongia sp. and Dysidea sp. The structures of the isolated compounds were fully characterized using NMR spectroscopic techniques and mass spectrometric analysis. All the isolated compounds were tested for their cytotoxic activity against human cancer cell lines (HePG-2, MCF-7, and HCT-116) and antibacterial activity against some Gram-positive and Gram-negative strains.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1016/j.tet.2014.12.035
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 2
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    Unlocking the potential of marine biodiscovery (2021)
    Royal Society of Chemistry
    Details
    Publication Date: 2024-02-07
    Description: The tremendous diversity of life in the ocean has proven to be a rich source of inspiration for drug discovery, with success rates for marine natural products up to 4 times higher than other naturally derived compounds. Yet the marine biodiscovery pipeline is characterized by chronic underfunding, bottlenecks and, ultimately, untapped potential. For instance, a lack of taxonomic capacity means that, on average, 20 years pass between the discovery of new organisms and the formal publication of scientific names, a prerequisite to proceed with detecting and isolating promising bioactive metabolites. The need for “edge” research that can spur novel lines of discovery and lengthy high-risk drug discovery processes, are poorly matched with research grant cycles. Here we propose five concrete pathways to broaden the biodiscovery pipeline and open the social and economic potential of the ocean genome for global benefit: (1) investing in fundamental research, even when the links to industry are not immediately apparent; (2) cultivating equitable collaborations between academia and industry that share both risks and benefits for these foundational research stages; (3) providing new opportunities for early-career researchers and under-represented groups to engage in high-risk research without risking their careers; (4) sharing data with global networks; and (5) protecting genetic diversity at its source through strong conservation efforts. The treasures of the ocean have provided fundamental breakthroughs in human health and still remain under-utilised for human benefit, yet that potential may be lost if we allow the biodiscovery pipeline to become blocked in a search for quick-fix solutions.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    Format: text
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 3
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    Mass spectrometry-based untargeted metabolomics approaches for comprehensive structural annotation of bioactive metabolites from bushy cashew (Anacardium humile) fruits (2023)
    Elsevier
    Details
    Publication Date: 2024-02-07
    Description: Anacardium humile (bushy cashew) is a native Brazilian plant with substantial pharmacological potential and noteworthy commercial significance in the food industry. This study introduces an untargeted metabolomics approach based on mass spectrometry for the comprehensive structural annotation of bioactive metabolites. The fruits were collected from three distinct sites and subjected to LC-HRMS/MS analysis. A total of eighty-eight compounds were putatively annotated across various metabolite classes. This unveiled a metabolic pro-file characterized by notable concentrations of polyphenols, including flavonoids, tannins, phenolic acids, and quinones, while aliphatic acids and terpenes were found in limited quantities. Noteworthy, no significant disparities in the metabolic content were observed among the collection sites. The three principal metabolites (peonidin 3-O-glucopyranoside, methylcyanidin and methyldelphinidin) underwent assessment for antioxidant activity via molecular docking analysis, subsequently generating structure-based feature pharmaco-phores. The process of annotation propagation yielded a comprehensive qualitative appraisal of the A. humile metabolome. The outcomes obtained offer potential candidates for further exploration of their nutraceutical attributes.(c) 2023 Published by Elsevier B.V. on behalf of SAAB.
    Type: Article , PeerReviewed
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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