In:
Gerontology, S. Karger AG, Vol. 61, No. 1 ( 2015), p. 24-31
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 New therapeutic targets are needed to fight aging-related diseases and increase life span. A new female-specific association with diseases and limited survival past 80 years was recently reported for a copy number variation (CNV) in the 〈 i 〉 CNTNAP4 〈 /i 〉 gene from the neurexin superfamily. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 We asked whether there are CNVs that are associated with aging phenotypes within other genes from the neurexin superfamily and whether this association is sex specific. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Select CNV polymorphisms were genotyped with proprietary TaqMan qPCR assays. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A case/control study, in which a group of 81- to 90-year-old community-dwelling Caucasians with no chronic diseases (case) was compared to a similar control group of 65- to 75-year-olds, revealed a negative association with healthy aging for the ins allele of common esv11910 CNV in the 〈 i 〉 CNTNAP2 〈 /i 〉 gene (n = 388; OR = 0.29, 95% CI: 0.14-0.59, p = 0.0004 for males, and OR = 0.82, 95% CI: 0.42-1.57, p = 0.625 for females). This male-specific association was validated in a study of an independent group of 76- to 80-year-olds. To look for a corresponding positive association of the allele with aging-related diseases, two case subgroups of 81- to 90-year-olds, one composed of individuals with cognitive impairment and the other with various diseases not directly related to the nervous system, such as cardiovascular diseases, etc., were compared to a healthy control subgroup of the same age. A positive male-specific association was found for both cases (OR = 2.75, p = 0.008 for association with cognitive impairment, and OR = 3.18, p = 0.002 for other diseases combined). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 A new male-specific association with aging is reported for a CNV in the 〈 i 〉 CNTNAP2 〈 /i 〉 gene. The polymorphism might be useful for diagnosing individual genetic predispositions to healthy aging versus aging complicated by chronic diseases.
Type of Medium:
Online Resource
ISSN:
0304-324X
,
1423-0003
Language:
English
Publisher:
S. Karger AG
Publication Date:
2015
detail.hit.zdb_id:
1482689-6
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