Keywords:
Natural products.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (365 pages)
Edition:
1st ed.
ISBN:
9781681085340
Series Statement:
Frontiers in Natural Product Chemistry ; v.3
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5044190
DDC:
547.70000000000005
Language:
English
Note:
Intro -- CONTENTS -- PREFACE -- List of Contributors -- Microbial Involvement in the Production of Natural Products by Plants, Marine Invertebrates and Other Organisms -- Lesley-Ann Giddings1,* and David J. Newman2 -- 1. INTRODUCTION -- 2. MARINE-DERIVED BIOACTIVE AGENTS AND MICROBES -- 2.1. Pederin, Mycalamides, Onnamides And Similar Molecules -- 2.1.1. Actual Producers of Pederin-related Molecules -- 2.2. Trabectedin, A Naphthyridinomycin / Tetrahydroisoquinoline Derivative -- 2.2.1. Actual Source of Trabectedin -- 2.3. Didemnins and Aplidine -- 2.4. Bryostatins -- 2.5. Kahalalides -- 2.6. Dolastatins -- 3. PLANT-DERIVED BIOACTIVE AGENTS AND MICROBES -- 3.1. Camptothecins -- 3.2. Taxol -- 3.2. Endophytes and Taxol -- 3.3. Maytansine and Endophytes -- 3.4. Vinca Alkaloids -- 3.5. Aloe-emodin, Emodin and Hypericin -- 3.6. Podophyllotoxin -- 3.7. Homoharringtonine -- 3.8. Artemisinin -- 3.9. Comments on Plant Endophytes -- 4. MICROBES AND TERRESTRIAL ARTHROPODS -- 4.1. Dentigerumycin and Other Agents -- 5. MICROBE-MICROBE INTERACTIONS -- 5.1. Fungi and Bacteria: Rhizoxin and Other Burkholderia-associated Compounds -- 5.2. Mimicking in situ Microbial Interactions -- CONCLUSIONS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- The Chemical Biology of Natural Product Biosynthesis: Chemical Tools for the Proteomic Analysis of Nonribosomal Peptide Synthetases -- Fumihiro Ishikawa1,* and Hideaki Kakeya2,* -- INTRODUCTION -- Nonribosomal Peptide Synthetase Biosynthetic Enzymes -- Adenylation Domains -- Conventional Strategies to Detect and Assess the Enzymatic Activities of the Adenylation Domains in Nonribosomal Peptide Synthetases -- Small-molecule Inhibitors for Adenylation Domains -- Design of Activity-based Probes for Adenylation Domains -- Inhibition Studies of Adenylation Domains -- Labeling Studies of Adenylation Domains.
,
Profiling Nonribosomal Peptide Synthetase Activities -- Profiling of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by Competitive Activity-based Protein Profiling -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Current Knowledge and Future Perspectives of Oligosaccharides Research -- Henrique S. Arruda1,*, Gustavo A. Pereira1, Martha E. F. Almeida2, Iramaia A. Neri-Numa1, Renata A. S. Sancho1, Gustavo Molina1,3 and Glaucia M. Pastore1 -- INTRODUCTION -- OLIGOSACCHARIDES: DEFINITION, PHYSICOCHEMICAL AND TECHNOLOGICAL PROPERTIES -- CLASSES OF OLIGOSACCHARIDES -- Fructooligosaccharides -- Maltooligosaccharides -- Isomaltooligosaccharides -- Gentiooligosaccharides -- Pectic Oligosaccharides -- Xylooligosaccharides -- Arabinooligosaccharides -- Chitooligosaccharides -- Galactooligosaccharides -- Raffinose Family Oligosaccharides -- Lactosucrose -- Lactulose -- Isomaltulose or Palatinose -- Glycosylsucrose -- Other Classes of Oligosaccharides -- NATURAL SOURCES AND STRATEGIES FOR OBTAINING OLIGOSACCHARIDES -- Oligosaccharides Obtained from Chemical Synthesis -- Depolymerisation of Polysaccharides by Chemical and Physical Processes for the Production of Oligosaccharides -- Biotechnological Production of Oligosaccharides -- Bioproduction of FOS -- Bioproduction of GOS -- General Perspectives for the Bioproduction of Oligosaccharides -- HEALTH BENEFITS OF OLIGOSACCHARIDES -- Effect in the Immune System -- Management of Constipation Symptoms -- The Role of Prebiotics in Gastrointestinal Disorders and Bowel Inflammation -- Effect of NDOs on Mineral Absorption -- Regulation of Glycaemia -- Regulation of Lipidic Metabolism -- Other Functionalities of NDOs -- GENERAL APPLICATIONS IN SCIENCE AND TECNOLOGY -- CONCLUSION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES.
,
The Treatment of Pain with Topical Sesquiterpenes -- James D. Adams*, Ian S. Haworth, Adriana Coricello, Filomena Perri, Christopher Nguyen, Francesca Aiello, Travis J. Williams and Eric J. Lien -- INTRODUCTION -- The Carpenter Approach to Pain -- Pain Cycle -- Receptor Targets in Pain Control -- Sesquiterpene Chemistry and Pharmacology -- Design of COX2 Inhibitors -- Design of Inhibitors of COX2 Expression -- CONCLUSIONS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- The Biological Activities and Synthesis of 2,6-Disubstituted Piperidinols -- Yasunao Hattori1 and Hidefumi Makabe2,* -- INTRODUCTION -- BIOLOGICAL ACTIVITIES OF 2,6-DISUBSTITUTED PIPERIDINOLS -- 1. Inhibition of Superoxide Anion Production -- 2. Anticonvulsant Activity -- 3. DNA-Damaging Activity -- 4. Antinociceptive Profile -- 5. Neurotoxic Damage -- 6. Antibacterial Activity -- 7. Antiparasitic Activity -- 8. Plant Growth Inhibitory Activity -- 9. Inhibition of Fucosidase -- SYNTHESIS OF 2,6-DISUBSTITUTED PIPERIDINOLS -- 1. Spectaline and Related Compounds -- 2. (−)-Morusimic Acid D and Related Compounds -- 3. (+)-Julifloridine and Related Compounds -- 4. Juliprosine and Related Compounds -- 5. 1-Deoxyfuconijirimycin and Its Analogs -- CONCLUSION -- ABBEREVIATIONS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Plant Isoflavones, their Impact on Life Sciences, Medicine and Industry -- Grzegorz Grynkiewicz* -- INTRODUCTION -- ISOFLAVONES IN THE POOL OF POLYPHENOLIC SECONDARY METABOLITES - SIMILARITIES AND DISTINCTIONS -- Early Research on Plant Flavonoids -- Development of Modern Analytical Techniques for Phytochemical Studies, Food Analysis and Pharmaceutical Research Involving Isoflavones -- Biogenesis, Biotransformations and Metabolomics of Isoflavones -- Isoflavones as Constituents of Diet -- Bioavailability and Metabolism -- Microbial Biotransformations.
,
ISOFLAVONES AS PHYTOESTROGENS AND EMERGENCE OF ISOFLAVONE PHARMACOLOGY -- Daidzein -- Genistein -- Ipriflavone -- Phenoxodiol -- Puerarin -- Rotenone -- SOY ISOFLAVONES, THEIR SIGNIFICANCE FOR FOOD AND HEALTHCARE -- CHEMICAL SYNTHESES OF ISOFLAVONES AND THEIR DERIVATIVES -- Transformations of Chalcones -- Coupling of Aromatic and Heterocyclic Synthons -- Derivatization of Natural Isoflavones -- Isotopic Labeling -- Protein Conjugation for Immunoassays -- Synthesis of Metabolites -- Chemical Glycosylation -- CONCLUSIONS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Natural Benzophenones from Clusiaceae Family: Structural Diversity and Biological Activities -- Ângela Maria Almeida Lima and Róbson Ricardo Teixeira* -- 1. INTRODUCTION -- 2. STRUCTURAL DIVERSITY OF BENZOPHENONES EXTRACTED FROM NATURAL SOURCES -- 2.1. Benzophenones isolated from Clusiaceae family species -- 2.3. Classification of the Benzophenones -- 2.2. Biosynthesis of the Benzophenones -- 3. BIOLOGICAL ACTIVITIES OF NATURAL BENZOPHENONES -- 3.1. Leishmanicidal, Trypanocidal and Antiplasmodial Activities -- 3.2. Antimicrobial, Antibacterial, and Antifungal Activities -- 3.3. Anti-HIV and Anti-hepatitis Virus Activities -- 3.4. Anti-inflammatory Activity -- 3.5. Antioxidant Activity -- 3.6. Cytotoxic Activity -- 3.7. Antidepressant, Neuroprotective and Hepatoprotective Activities -- CONCLUDING REMARKS -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- SUBJECT INDEX.
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