Publication Date:
2018-06-29
Description:
Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice, Published online: 28 June 2018; doi:10.1038/s41467-018-04982-3 The valine-citrulline dipeptide, which is used as a cleavable linker for antibody-drug conjugates, is instable in mouse plasma. Here, the authors developed a glutamic acid–valine–citrulline tripeptide sequence as a stable alternative that still is susceptible to cathepsin-mediated cleavage.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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