Publication Date:
2018-06-20
Description:
Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role, Published online: 19 June 2018; doi:10.1038/s41467-018-04760-1 Cytoplasmic PTEN is a tumor suppressor that antagonises PI3K signalling. Here, the authors show that nuclear PTEN can interact with the spliceosomal proteins and drive pre-mRNA splicing in a phosphatase-independent manner, in particular, PTEN depletion promotes Golgi extension and secretion through GOLGA2 exon skipping.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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