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  • Articles  (504)
  • Geosciences  (457)
  • Economics  (47)
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  • Articles  (504)
  • 1
    Publication Date: 2017-04-05
    Description: S100A1 is a member of the S100 family of Ca 2+ -binding proteins and regulates several cellular processes, including those involved in Ca 2+ signaling and cardiac and skeletal muscle function. In Alzheimer's disease, brain S100A1 is overexpressed and gives rise to disease pathologies, making it a potential therapeutic target. The 2.25 Å resolution crystal structure of Ca 2+ -S100A1 is solved here and is compared with the structures of other S100 proteins, most notably S100B, which is a highly homologous S100-family member that is implicated in the progression of malignant melanoma. The observed structural differences in S100A1 versus S100B provide insights regarding target protein-binding specificity and for targeting these two S100 proteins in human diseases using structure-based drug-design approaches. The crystal structure of human Ca 2+ -bound S100A1 at 2.25 Å resolution is described.
    Electronic ISSN: 1744-3091
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 29 (1981), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: An underground gravity study was carried out under extreme conditions of the Alpine regions. The lead–zinc mine Bleiberg, Carinthia, was selected as an example to show the possibilities and limitations of the subsurface gravity method. For in situ density determinations, gravity measurements were made in two vertical mine shafts passing through Triassic sedimentary rocks of the Bleiberg Unit. The main prblem in gravity data reduction in extremely rugged topography is the accurate calculation of the terrain effect on underground stations. A general discussion of the various corrections required for the gravity measurements in the mine is presented. The mean interval densities in the two shafts, in limestone, dolomite, and schists formations, were determined as 2.76 and 2.77 g/cm3, respectively, with an accuracy of better than 0.01 g/cm3 for a depth interval of 50 m. The interval densities provide valuable information about the lithological and structural changes in the shaft surroundings and also agree well with the representative hand sample densities.In the second part, the applications of subsurface horizontal gravity surveys in exploration are discussed. Since the influence of topography is less underground because of the greater distance to the surface, subsurface surveys have definite advantages over surface surveys and can be very helpful in locating anomalous density zones in the mines. An example of gravity survey with a station spacing of 10 m at a depth of about 540 m is presented.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 30 (1982), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Boston, USA and Oxford, UK : Blackwell Publishers Inc.
    Growth and change 29 (1998), S. 0 
    ISSN: 1468-2257
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Notes: The literature suggests that asymmetric information in less developed economies may contribute to credit-market failure that is reflected in the economic efficiency of lending firms. This research tests whether rural banks located in the Lower Mississippi Delta Region (LMDR), the poorest rural region in the U.S., are less efficient than other rural banks. Rural banks in the LMDR are found to be technically less efficient than their non-LMDR counterparts
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Growth and change 29 (1998), S. 0 
    ISSN: 1468-2257
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Notes: Many states are striving to meet public demand for accountability by “benchmarking”—setting social goals for the state and tracking progress in meeting the goals. However, states are finding it difficult to set realistic targets and to assess the impacts of policy on achievement of the targets without a framework that models the relationships among policy targets, policy actions and social and economic forces outside the control of policymakers. This paper develops a dynamic simulation model of one “benchmark” (poverty incidence) in Oregon, linking transitions into and out of poverty to various events (increased earnings, or having a child as a teenager, for example), and linking these events to policy. The simulation results suggest that, with current policies, Oregon will come close to achieving its poverty benchmark target of 11 percent by the year 2000 if economic conditions remain favorable. The model is used to examine the impact on poverty incidence of three policy strategies: reducing high school dropout and teen pregnancy rates, increasing the effectiveness of social support programs to JOBS participants, and boosting job growth. The simulation results suggest that when assessing the state's performance or “grading” the observed trend in the poverty benchmark, policymakers should take into account the performance of the state (and national) economy. The impact of policy efforts to reduce poverty is limited because many poverty spells are caused largely by events not affected by current state policies.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of regional science 19 (1979), S. 0 
    ISSN: 1467-9787
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Boston, USA and Oxford, UK : Blackwell Publishers Inc.
    Journal of regional science 37 (1997), S. 0 
    ISSN: 1467-9787
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Notes: A linear programming technique is used to measure total factor productivity change in the contiguous 48 states during the period 1977 to 1986. The technique allows the decomposition of productivity change into its constituent parts: technological change, changes in pure technical efficiency, and changes in scale economies. This decomposition is used to identify “innovative” states that are pushing out the production frontier as opposed to states that are primarily in the process of ‘catching-up.’
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of regional science 20 (1980), S. 0 
    ISSN: 1467-9787
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 22 (1984), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 22 (1984), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Effective management of a ground-water system requires description and prediction of the transport and fate of contaminants in that system. This can be facilitated by using mathematical models which accurately represent the physical phenomena operative in the system. One of the most significant phenomena impacting the transport of many organic pollutants is partitioning between the solid (soil) and aqueous (ground-water) phases.The tendency of a contaminant to partition may be roughly approximated from measurements of such constitutive properties as the octanol: water partition coefficient of the contaminant and organic carbon content of the soil. Such rough approximations provide a basis for cursory appraisal, but are inadequate for quantitative system descriptions, particularly where nonlinear equilibrium sorption, kinetically dependent partitioning, or irreversible and/or hysteretic phase distribution phenomena are operative. Accurate simulation of solute transport frequently requires the incorporation of kinetic parameters and/or a nonlinear isotherm relationship to define transport phenomena in the fundamental equations governing mass transport. Laboratory measurements may be utilized to assess sorptive factors of importance, kinetic properties of an organic solute and a soil system, and equilibrium partitioning relationships. Such measurements can be utilized to provide more accurate modeling of contaminant transport.
    Type of Medium: Electronic Resource
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