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The binding of FITC-insulin to ANAE-positive cells in rat thymus (1988)

Hofert, J. F. ; Mahowald, T. N. ; Mahowald, N. A. ; [et al.]

Springer

Cellular and molecular life sciences 44 (1988), S. 37-38

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ISSN: 1420-9071

Keywords: Thymus ; thymic macrophages ; ANAE ; insulin ; FITC-insulin ; diabetes mellitus

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary To determine if thymic macrophages have insulin receptors, alternate sections of rat thymus were stained with FITC-insulin and examined for nonspecific esterase (ANAE) activity. Cells showing a diffuse ANAE staining pattern also bound FITC-insulin. These cells were concentrated in the cortico-medullary border and increased in number following administration of cortisol. Thymic macrophages may be insulin-dependent and therefore could be malfunctional in diabetes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01960236

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