ISSN:
1572-8870
Keywords:
DNA
;
cleavage
;
metal complexes
;
ruthenium
;
platinum
;
oxo
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The chemistry of new families of DNA cleavage agents based on oxoruthenium(IV) or diplatinum pyrophosphite complexes is reviewed. The ruthenium complexes derived from Ru(tpy)(bpy)O2+ (tpy, 2, 2, 2′-terpyridine; bpy, 2, 2′-bipyridine) are effective DNA cleavage agents both electrocatalytically or thermally. The stoichiometric reaction quantitatively produces Ru(II), which also binds to DNA covalently in a slow, follow-up reaction. The cleavage by Pt2(pop)4 4− (pop, P2O5H2) is photoactivated and proceeds via H-atom abstraction by the platinum complex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00696752
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