ISSN:
1573-8744
Keywords:
cancer chemotherapy
;
cell kinetics
;
cell cycle specific drugs
;
methotrexate
;
cytosine arabinoside
;
cyclophosphamide
;
cell generation time distribution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A general consideration of cancer chemotherapy is presented consisting of a brief description of cell kinetics and some of the biochemical events involved. Models of local tissue and cell uptake of drugs are presented which include various diffusion and mass transport steps. The complex interactions of saturable transport, cell binding, and other pharmacokinetic parameters on the concentration levels of methotrexate in rat bone marrow and other tissues have been studied. A semiquantitative pharmacokinetic model may be used when a critical concentration level of a drug is known. By using a pharmacokinetic model to predict the time that the local drug concentration is above this minimum, one can deduce the extent of cell kill to be expected, as has been done for methotrexate. Jusko (24,25)has developed quantitative models for cell cycle specific drugs such as vinblastine and cytosine arabinoside and non cell cycle specific drugs such as alkylating agents. Himmelstein and Bischoff (26,27)have developed quantitative models which also consider the cell generation time distribution. These models were used to attempt to predict the experimental results for cytosine arabinoside on the mouse L1210 leukemia system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059786
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