ISSN:
1573-8744
Keywords:
cancer chemotherapy
;
ARA-C (cytosine arabinoside)
;
L1210 mouse leukemia
;
mathematical predictions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The results of clinical treatment of the L1210 mouse leukemia with cytosine arabinoside have been modeled with a direct action exponential growth model. Experimental growth kinetic and pharmacokinetic data were used to evaluate portions of the model. The data from a single in vivodrug-cancer cell interaction experiment have been used to determine the interaction coefficients. The model has then been used to simulate the results of various treatment schedules of the drug on the cancer system, with rather good agreement with experimental data.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01060028
Permalink
