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  • 1
    Electronic Resource
    Electronic Resource
    Liver transplantation in patients with Budd-Chiari syndrome (1995)
    Springer
    Transplant international 8 (1995), S. 312-316 
    Details
    ISSN: 1432-2277
    Keywords: Budd-Chiari syndrome ; liver transplantation ; Liver transplantation ; Budd-Chiari syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with Budd-Chiari syndrome (obstruction of the hepatic veins) and associated hepatic insufficiency may be candidates for orthotopic liver transplantation (OLT). In our series of 405 OLT patients, 3 were transplanted due to Budd-Chiari syndrome (0.7%). The indication for liver transplantation in these patients was severe hepatic insufficiency (chronic in two and acute in the third one). Morphologic study of the obstructions revealed apparently different causes, including thrombi, membranous webs in hepatic veins, and hydatid cyst compression. The surgical technique employed in these transplantations was similar to that for other etiologies. Due to its implications for the future course of OLT, it is important to determine the exact etiology of Budd-Chiari syndrome in the pretransplant period and to treat the patients with early and long-term anticoagulant therapy to avoid syndrome recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346886
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  • 2
    Electronic Resource
    Electronic Resource
    Lipid abnormalities in stable liver transplant recipients – effects of cyclosporin, tacrolimus, and steroids (1998)
    Springer
    Transplant international 11 (1998), S. 137-142 
    Details
    ISSN: 1432-2277
    Keywords: Key words Lipoproteins ; liver transplantation ; immunosuppression ; Liver transplantation ; lipoproteins ; immunosuppression ; Immunosuppression ; liver transplantation ; lipoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dyslipidemia is common after liver transplantation, but the underlying mechanisms are largely unknown. We studied the lipid profile of 27 liver transplant recipients randomized to receive either cyclosporin (CyA, n = 14) or tacrolimus (n = 13) and compared them with 20 healthy, matched controls. Before transplantation, patients presented low total and low-density lipoprotein (LDL) cholesterol (as compared to controls) that increased shortly, i. e., 3 months, after transplantation. Eighteen months post-transplantation, total and LDL cholesterol levels decreased to pretransplant values but tended to remain higher in CyA-treated patients. However, at that time, prednisone treatment was more prevalent among CyA-treated than tacrolimus-treated patients and fully accounted for the difference in cholesterol levels. Indeed, regardless of therapy, patients not receiving prednisone exhibited lower cholesterol levels than prednisone-treated patients and controls. We conclude that prednisone therapy, rather than CyA or tacrolimus immunosuppression, seems to be the major determinant of increased cholesterol levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050117
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical significance of hepatitis C virus (HCV) infection in liver transplant recipients (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 965-969 
    Details
    ISSN: 1573-2568
    Keywords: liver transplantation ; PCR ; posttransplant hepatitis ; serology ; HCV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatitis C virus (HCV) infection was studied in 60 liver transplant recipients. Antibodies to HCV were tested by both a second-generation ELISA test and a four-recombinant immunoblot assay (4-RIBA) just before the transplant and every three months thereafter. HCV RNA detection was performed by polymerase chain reaction (PCR) at least three times after the transplant in all the patients. Thirty-nine patients tested negative by ELISA before LT (group A), 14 patients tested positive by both serological tests (group B), and seven tested positive only by ELISA (group C). Posttransplant hepatitis was diagnosed in 11/14 in group B in comparison with 3/39 in group A (P〈0.001) and 1/7 in group C (P〈0.05). HCV RNA was detected in the sera of 14/14 patients in group B but in only 1/7 in group C and 6/39 in group A. Only 2/15 patients developed posttransplant hepatitis in the absence of HCV RNA detection. These data suggest that HCV is the major cause of hepatitis after LT. Patients HCV seropositive by RIBA test before the transplant formed a group of high-risk patients for developing viremia and hepatitis afterwards.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087545
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