ISSN:
1573-7233
Keywords:
adhesion molecules
;
angiongenesis
;
leukocyte-endothelial interactions
;
selectins
;
integrins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted by cancer or immune cells can modulate the endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial interaction is often low and heterogeneous in angiogenic tumor vessels and why activated lymphocytes adhere nonuniformly to tumor vessels when injected into the tumor's blood supply.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00437472
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