ISSN:
1573-6903
Keywords:
L-α-aminoadipate
;
kynurenate
;
kynurenine
;
aminotransferase
;
astrocyte
;
neurodegeneration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Intracerebral administration of L-α-aminoadipic acid (L-AAA) at 500 mg/kg body weight to rats caused a complex behavioral change with sporadic wet-dog shakes. Animals developed severe limbic seizures between 1 and 6 h after L-AAA injection, characterized by generalized convulsions. Twenty days after L-AAA injection kynurenine aminotransferase (KAT) activity measured in hippocampal brain tissue slices prepared with a McIlwain chopper at 30 μm showed a significant 43% decrease. Subcutaneous injection of kynurenine at 500 mg/kg showed a 63% increase in KAT activity twenty days later. This increase was offset by a concomitant administration of 500 mg/kg L-AAA stereotaxically on day one. In astrocyte culture kynurenic acid synthesis is inhibited by L-AAA and L-pipecolic acid. The possible involvement of kynurenic acid in the modulation of neuronal degeneration is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1022035926832
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