ISSN:
1420-9071
Keywords:
Serotonin
;
5-hydroxytryptamine
;
tetanus toxin
;
pargyline
;
alphamethyldopa
;
indolamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Mice injected with tetanus toxin (TTx) showed an increase of 5-hydroxytryptamine (serotonin, 5-HT) levels in the central nervous system. The increment was not uniform thoughout the central nervous system. Particularly significant were the 25% and 80% increases observed, respectively, in whole brain and spinal cord. The levels of dopamine and norepinephrine remained unchanged. The subsequent studies of 5-HT turnover revealed a synthesis rate in the tetanic animals that was almost double that of controls. The degradation rate of the amine as well as the levels of 5-hydroxyindolacetic acid were unaffected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01940431
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