ISSN:
1573-8221
Keywords:
alcohol dehydrogenase
;
immunization
;
alcoholism
;
behavior
;
rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Active immunization of white rats with alcohol dehydrogenase (horse ADH-1), a major ethanol-metabolizing enzyme shown to cause considerable and long-term inhibition of alcohol consumption, did not have adverse effects on their behavior. Rather, the rats showed enhanced motor and orienting-exploratory activities, developed conditioned responses (with both positive and negative reinforcements) more readily, and spent less time in a state of immobilization in the forced swimming test as compared with nonimmunized controls.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446457
Permalink
