ISSN:
1432-0533
Keywords:
Key words NACP
;
Synuclein
;
Multiple system
;
atrophy
;
Neuronal cytoplasmic inclusions
;
Glial
;
cytoplasmic inclusions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid β component of Alzheimer’s disease amyloid precursor protein (NACP/α-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004010050917
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