ISSN:
1432-0428
Keywords:
Rat
;
islets of Langerhans
;
oestradiol treatment
;
adrenal glands
;
corticosterone treatment
;
insulin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Ovarian-adrenal interactions on insulin secretion during oestradiol treatment were studied in sham-operated, ovariectomized and adrenalectomized-ovariectomized female rats, the latter thus treated to suppress interference from endogenous hormones. Islets of Langerhans isolated from oestradiol or oestradiol + corticosterone treated and control rats were incubated with various glucose concentrations. Oestradiol treatment enhanced basal and glucose stimulated insulin secretion from sham-operated (+12%) or ovariectomized rats (+24%). This effect disappeared in adrenalectomized-ovariectomized rats but reappeared when adrenalectomized-ovariectomized rats were treated with oestradiol + corticosterone (+37%). A 14-day oestradiol treatment had a trophic effect on total protein content independent of adrenal presence (+14%; +15%; +31%; +23% versus respective control groups). Our data demonstrate that corticosterone is necessary for the stimulating effect of oestradiol on insulin secretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00252268
Permalink
