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  • Verapamil  (1)
  • rare earth magnetism  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Verapamil enhanced in vitro chemosensitivity of a murine bladder carcinoma, FCB (1986)
    Springer
    Urological research 14 (1986), S. 195-200 
    Details
    ISSN: 1434-0879
    Keywords: Verapamil ; Adriamycin ; Thiotepa ; Bladder cancer ; Calcium channel blockers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The in vitro enhancement of chemotherapeutic efficacy by verapamil, a calcium antagonist, was assessed using FCB, a transplantable murine transitional cell carcinoma. Exponentially growing FCB cells were partially resistant to treatment with both thiotepa (10-4 M) and Adriamycin (10-5M), however, there was a significant reduction in cell growth when either agent was administered in combination with verapamil (10-5 M); the effect was evident over a wide range of drug concentrations (10-4–10-9 M). There was also a pronounced inhibition of DNA precursor incorporation when verapamil was used in combination with either agent. Fluorometric analysis of Adriamycin uptake indicated that verapamil caused an increase in the intracellular concentration of the agent. The data presented are consistent with the postulate that verapamil enhances chemotherapeutic efficacy by altering cellular permeability to the cytotoxic agents. Our study indicates that the use of verapamil in combination with cytotoxic agents for intravesical chemotherapy of bladder tumors may prove to be beneficial in human patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441113
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High pressure μSR studies: rare earths and related materials (2000)
    Springer
    Hyperfine interactions 128 (2000), S. 275-303 
    Details
    ISSN: 1572-9540
    Keywords: muon spin rotation/relaxation ; rare earth magnetism ; frustrated magnets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract After a short introduction to μSR with respect to the study of magnetic properties, followed by a brief outline of the principle of the high pressure-low temperature μSR spectrometer installed at the Paul Scherrer Institute, we discuss some measurements on rare earth materials employing this instrument. They are concerned with: (1) The pressure dependence of the spin turning process in ferromagnetic Gd. (2) The volume dependence of the internal magnetic field in the heavy rare earth metals Gd, Dy, and Ho in their ordered magnetic states. (3) The response of the (first order) magnetic transition in the frustrated antiferromagnets of type RMn2 (R = Y,Gd) to pressure. (4) The variation of magnetic parameters with pressure in La2CuO4 (powder sample), the antiferromagnetic parent compound of the high TC superconductors of type La2−x(Sr, Ba)xCuO4. In conclusion a short outlook on further developments is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012695902178
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    Paper (German National Licenses)
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