ISSN:
1573-2568
Keywords:
INFLAMMATORY BOWEL DISEASE
;
TRINITROBENZENESULFONIC ACID
;
HISTOLOGY
;
ULTRASTRUCTURE
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Inflammatory bowel disease (IBD) of humans is achronic and devastating disease of unknown etiology.Models of acute colitis in animals have been achieved byintrarectal administration of agents such as 2,4,6-trinitrobenzenesulfonic acid (TNBS) intorat colon. This agent induces focal inflammation andalterations in the colon with features similar to thosefound in chronic inflammatory diseases in humans. The aim of this study was to assess the effectof TNBS administration on histological andultrastructural features of the rat colon, especially inareas not affected by transmural inflammation. Also in areas without transmural inflammation, weobserved a significant increase in crypt diameter and inthe number and area of the goblet cells, as well asalterations in the contents of mucin in goblet cells. We conclude that TNBS treatment in rats led tosevere changes in normal architecture of the colon andalso in damaged areas where no direct inflammation wasproduced.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026651408998
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