ISSN:
1432-0428
Keywords:
Type 1 diabetes
;
immunoglobulin allotypes
;
HLA
;
GM
;
KM
;
INV
;
disease marker
;
genetic linkage
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We analyzed 88 unrelated subjects with Type 1 (insulin-dependent) diabetes and 64 sibling controls (maximum one per diabetic) for associations between immunoglobulin allotype antigens (GM and KM) and Type 1 diabetes. None were found. However, we did find interactions between GM, HLA-DR, and Type 1 diabetes (significant or of borderline significance after considering the effect of multiple tests): possession of Glm(2) appeared to increase susceptibility to diabetes in individuals who had HLA-DR3 but not HLA-DR4, while possession of G3m(5) appeared to increase susceptibility in individuals who had HLA-DR4 but not HLA-DR3. These results suggest that genetic predisposition to Type 1 diabetes is partially determined by alleles at the GM locus (or a locus in linkage disequilibrium with GM) interacting with alleles at the HLA-DR locus (or a locus in linkage disequilibrium with HLA-DR).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00290384
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