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  • 1
    Electronic Resource
    Electronic Resource
    Lesional alopecia areata T lymphocytes downregulate epithelial cell proliferation (1997)
    Springer
    Archives of dermatological research 289 (1997), S. 384-388 
    Details
    ISSN: 1432-069X
    Keywords: Key words Alopecia areata ; T-cell clones ; Keratinocytes ; TNF-α ; IFN-γ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Alopecia areata is characterized by peribulbar infiltration by activated T cells. The function of these T cells in the pathogenesis is unknown. To elucidate the potential role of lesional T cells in the regulation of hair growth, T-cell clones from the margin of involved alopecia areata lesions from three patients were obtained by cloning, using the limiting dilution method. Of these T-cell clones, 31 were CD4 + CD8 – , 15 were CD8 + CD4 – and 2 were CD4 – CD8 – . The T-cell clones were activated and the supernatant harvested 24 h later and tested for its capacity to regulate proliferation of neonatal keratinocytes. The majority of the T-cell clone supernatants inhibited epithelial cell proliferation in a dose-dependent fashion. When the cytokine profiles of conditioned T-cell medium were compared with the growth-regulatory capacity, it was found that T-cell clones that released high amounts of interferon gamma and/or tumour necrosis factor alpha inhibited keratinocyte growth. In conclusion, T cells derived from the margin of active alopecia areata lesions are able to downregulate epithelial cell proliferation. This points to an important role of the immune system, especially the T cells, in this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050209
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Parallel measurements of heat production and thermogenin content in brown fat cells during cold acclimation of rats (1986)
    Springer
    Bioscience reports 6 (1986), S. 31-38 
    Details
    ISSN: 1573-4935
    Keywords: brown fat cells ; heat production and thermogenin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The maximum thermogenic capacity of brown fat cells from control and cold acclimated rats was measured using a continuous-flow microcalorimetric system, The content of the 32.000 D, brown fat specific protein, thermogenin, was measured in the cells used for heat production measurements by competitive ELISA. The ratio between the maximal thermogenic capacity and the amount ofthermogenin for control and cold acclimated rats was compared. It was found that the ratio between the two parameters decreased during cold acclimation due to a decrease in maximal thermogenic capacity and an increase in the amount ofthermogenin, indicating regulation of heat production either at thermogenin or receptor level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01145176
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    Paper (German National Licenses)
    Fulltext
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