ISSN:
1432-1432
Schlagwort(e):
Prebiotic
;
Polymerization
;
Deoxythymidine oligonucleotides
;
Deoxythymidine 5′-monophosphate
;
P1, P2-dideoxythymidine 5′-pyrophosphate
;
4-amino-5-imidazolecarboxamide
;
Cyanamide
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
Notizen:
Summary When an aqueous solution (pH 7.0) of deoxythymidine 5′-phosphate, 4-amino-5-imidazolecarboxamide and cyanamide was dried and heated for 18 h at 60°C, P1, P2-dideoxythymidine 5′-pyrophosphate (I) was formed in a 58% yield. Oligonucleotides were not detected in the reaction product. Under conditions employed in the above reaction, (I) was shown to be stable. In prebiotic polymerization reactions employing deoxythymidine 5′-triphosphate as the polymerizing species, (I) could therefore function as a primer and minimize the formation of cyclic nucleotides.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01764594
Permalink
