ISSN:
0749-1581
Keywords:
1H NMR
;
Urine
;
Metabolites
;
Platinum anticancer drug
;
Carboplatin
;
Paraplatin
;
CBDCA
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Samples of urine from a patient obtained before and after treatment with 300 mg of the anticancer drug [Pt(II)(NH3)2(CBDCA)] (carboplatin, “Paraplatin”, where CBCDA is 1,1-dicarboxycyclobutane) have been analysed using 500 MHz 1D and 2D 1H NMR spectroscopy. Peaks for the intact drug and the free ligand CBDCA have been assigned and are present in a mol ratio of ca. 5:1. Only about one half of the total Pt in the sample was present as intact drug. Relative to creatinine and citrate, the excretion of hippurate increased by a factor of ca. 4 after drug treatment. This work suggests that NMR spectroscopy can play a valuable rǒle in studies of carboplatin metabolism.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260291321
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