GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 389-401 
    ISSN: 1437-1588
    Keywords: SchlüsselwörterVirusbedingte hämorrhagische Fieber (Ebola Marburg ; Lassa ; Krim-Kongo) ; Pest ; Seuchenhygiene ; Quarantäne ; Internationale Gesundheitsvorschriften ; Reisemedizin ; Tropenkrankheiten ; Emerging diseases ; öffentlicher Gesundheitsdienst ; Zivilmilitärische Zusammenarbeit ; Key words Viral Haemorrhagic Fevers (Ebola-Marburg Viral Diseases ; Lassa Fever ; Crimean-Congo Haemorrhagic Fever) ; Pneumonic Plague ; Control of Epidemics ; Quarantine ; International Health Regulations ; Travelling Medicine ; Tropical Diseases ; Emerging Diseases ; Public Health (Services) ; Civilian-Military Co-operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary At present, the importation into Germany of life-threatening and highly contagious diseases such as pneumonic plague and Ebola is unlikely, but cannot be ruled out. In spite of the extreme rarity of these diseases, guidelines are necessary to prevent the spread of these agents in case of their importation. In Germany, marked regional differences exist with respect to the development of emergency regulations and the availability of specialized centers for diagnostics and therapy. A federal framework is missing. A concept is presented here in which the capacity to respond is substantially augmented with limited additional cost through inter-regional cooperation using existing infrastructure and federally standardized procedures.
    Notes: Zusammenfassung Ein Einschleppen lebensbedrohender und zugleich hochkontagiöser Infektionskrankheiten wie Lungenpest oder Ebola-Fieber nach Deutschland erscheint zur Zeit nicht sehr wahrscheinlich, ist aber grundsätzlich nicht auszuschließen. Gerade wegen der Seltenheit des Auftretens einer solchen Erkrankung sind jedoch auch hierzulande Handlungsrichtlinien notwendig, um gegebenenfalls einer Verbreitung entgegenzuwirken. Die Entwicklung konkreter Schutzvorkehrungen und Handlungsalgorithmen sowie das Vorhalten geeigneter Diagnostik- und Behandlungseinrichtungen ist in den einzelnen Regionen Deutschlands sehr unterschiedlich ausgeprägt. Ein bundesweiter Rahmenplan fehlt. Der vorliegende Konzeptentwurf zeigt, wie die Vorsorge mit vertretbarem finanziellen Mehraufwand durch eine gemeinsame überregionale Nutzung der z. T. vorhandenen Infrastruktur und durch eine Vereinbarung bundeseinheitlicher Vorgehensweisen wesentlich verbessert werden kann.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1437-1588
    Keywords: Schlüsselwörter Tropenkrankheiten ; Virale hämorrhagische Fieber ; Lassa-Fieber ; Infektionsschutz ; Quarantäne ; BSL4 ; Seuchenhygiene ; Öffentliches Gesundheitswesen ; Rettungswesen ; Krankentransport ; Krankenpflege ; Schutzkleidung ; Kontaktpersonen ; Keywords Tropical Diseases ; Viral Haemorrhagic Fever ; Lassa-Fever ; Epidemic Control ; Preparedness Plans ; Quarantine ; BSL4 ; Patient Isolation ; Barrier Nursing ; Protective Equipment ; Contact Tracing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Patients infected with viral haemorrhagic fevers (VHF), pneumonic plague or zoonotic orthopoxvirus infections usually require intensive care and a special isolation. Contact persons must be traced and monitored. Last year our working group published a concept for the management and control of these life-threatening highly contagious diseases. Now the principles of our plan have been accepted. The development of guidelines for rapid reaction to those communicable diseases is an important task for all EU Member States. In Germany microbiological diagnosis is performed by a diagnostic centre (Biosafety-Level BSL4) and supported by a corresponding confirmation laboratory. At present four high security infectious disease units for patient care (HSIU) are available in Munich, Leipzig, Hamburg and Berlin. Another one located in Frankfurt will be functional by 2001. In addition to the HSIU a corresponding number of centres of competence shall be established in order to support and advise the hospitals initially treating the patients as well as the local public health officer. The risk categorisation for contact persons, which has been developed by our working group, has proved to be very useful in practice. Ambulances should be used for transfer of patients to the HSIU. So-called transport-isolators are not suitable for patients who are seriously ill. Air-based transport without using an isolator is a problem, since no decontamination procedure exists. As soon as the last HSIU in the Rhine Main area is working the centres of competence will be established. This will provide competent health care for VHF-patients and a convincing management for these kinds of threats to public health everywhere in Germany.
    Notes: Zusammenfassung Verschiedene virusbedingte hämorrhagische Fieber (VHF), Pocken (humane Affenpocken) sowie Lungenpest erfordern besondere Maßnahmen zum Schutz des Krankenhauspersonals und anderer Personen vor Ansteckung. Kontaktpersonen müssen ermittelt und überwacht werden, um eine Ausbreitung zu verhindern. Ein im Mai 1999 veröffentlichtes Konzept zum Management und zur Kontrolle dieser lebensbedrohenden hochkontagiösen Infektionskrankheiten wurde inzwischen mit Fachöffentlichkeit und Gesundheitsbehörden diskutiert. Bei den zwischenzeitlich aufgetretenen Fällen bestätigte sich das vorgeschlagene Vorgehen : In Deutschland werden die mikrobiologische Diagnostik und Differentialdiagnostik zentral von einem Zentrum der biologischen Sicherheitsstufe BSL4 und einem entsprechenden Bestätigungslabor vorgenommen. Für Isolierung und klinische Behandlung der Patienten stehen vier Behandlungszentren zur Verfügung, ein fünftes soll im nächsten Jahr betriebsbereit sein. Die zunehmende Inanspruchnahme zeigt, dass sich die vorgesehene Schwerpunktversorgung durchsetzt. Handelsübliche Transportisolatoren sind für schwer kranke Personen nicht geeignet. Ohne deren Verwendung können Luftfahrzeuge jedoch nicht regelrecht dekontaminiert werden. Transporte sollen daher grundsätzlich auf dem Landweg erfolgen. Zur Unterstützung und Beratung der erstversorgenden Krankenhäuser und der örtlich zuständigen Amtsärzte sollen um die Behandlungszentren sog. Kompetenzzentren entstehen. Der Personal- und Platzbedarf bei der Versorgung eines an einem VHF Erkrankten in fortgeschrittenem Stadium ist höher als erwartet. Die adäquate Versorgung von Kranken in sog. Bettisolatoren ist nicht möglich. Routinelaboruntersuchungen müssen in der Behandlungseinheit erfolgen. Maßnahmen zur Verhinderung der Weiterverbreitung müssen stärker koordiniert werden. Die von uns vorgeschlagene Einteilung der Kontaktpersonen wird um eine Auflistung der empfohlenen Maßnahmen ergänzt.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2017-12-16
    Description: Introduction Optimal targets for systemic oxygenation in paediatric critical illness are unknown. Observational data indicate that high levels of arterial oxygenation are associated with poor outcomes in resuscitation of the newborn and in adult critical illness. Within paediatric intensive care units (PICUs), staff prevent severe hypoxia wherever possible, but beyond this there is no consensus. Practice varies widely with age, diagnosis, treating doctor and local or national guidelines followed, though peripheral blood oxygen saturations (SpO 2 ) of 〉95% are often targeted. The overall aim of this pilot study is to determine the feasibility of performing a randomised trial in critically ill children comparing current practice of liberal SpO 2 targets with a more conservative target. Methods and analysis Oxy-PICU is a pragmatic, open, pilot randomised controlled trial in infants and children requiring mechanical ventilation and receiving supplemental oxygen for abnormal gas exchange accepted for emergency admission to one of three participating UK PICUs. The study groups will be either a conservative SpO 2 target of 88%–92% (inclusive) or a liberal SpO 2 target of 〉94%. Infants and children who fulfil all inclusion criteria and none of the exclusion criteria will be randomised 1:1 by a secure web-based system to one of the two groups. Baseline demographics and clinical status will be recorded as well as daily measures of oxygenation and organ support. Discharge outcomes will also be recorded. In addition to observational data, blood and urine samples will be taken to identify biochemical markers of oxidative stress. Outcomes are targeted at assessing study feasibility with a primary outcome of adequate study recruitment (target: 120 participants). Ethics and dissemination The trial received Health Research Authority approval on 1 June 2017 (16/SC/0617). Study findings will be disseminated in national and international conferences and peer-reviewed journals. Trial registration number NCT03040570.
    Keywords: Open access, Paediatrics
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2017-06-13
    Description: Introduction Over 18 000 children are admitted annually to UK paediatric intensive care units (PICUs), of whom nearly 75% receive respiratory support (invasive and/or non-invasive). Continuous positive airway pressure (CPAP) has traditionally been used to provide first-line non-invasive respiratory support (NRS) in PICUs; however, high-flow nasal cannula therapy (HFNC), a novel mode of NRS, has recently gained popularity despite the lack of high-quality trial evidence to support its effectiveness. This feasibility study aims to inform the design and conduct of a future definitive randomised clinical trial (RCT) comparing the two modes of respiratory support. Methods and analysis We will conduct a three-centre randomised feasibility study over 12 months. Patients admitted to participating PICUs who satisfy eligibility criteria will be recruited to either group A (primary respiratory failure) or group B (postextubation). Consent will be obtained from parents/guardians prior to randomisation in ‘planned’ group B, and deferred in emergency situations (group A and ‘rescue’ group B). Participants will be randomised (1:1) to either CPAP or HFNC using sealed, opaque envelopes, from a computer-generated randomisation sequence with variable block sizes. The study protocol specifies algorithms for the initiation, maintenance and weaning of HFNC and CPAP. The primary outcomes are related to feasibility, including the number of eligible patients in each group, feasibility of randomising 〉50% of eligible patients and measures of adherence to the treatment protocols. Data will also be collected on patient outcomes (eg, mortality and length of PICU stay) to inform the selection of an appropriate outcome measure in a future RCT. We aim to recruit 120 patients to the study. Ethics and dissemination Ethical approval was granted by the National Research Ethics Service Committee North East—Tyne&Wear South (15/NE/0296). Study findings will be disseminated through peer-reviewed journals, national and international conferences. Trials registration number NCT02612415; pre-results.
    Keywords: Open access, Paediatrics
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...