ISSN:
1432-2072
Keywords:
Ondansetron
;
Blood brain barrier
;
Cerebrospinal fluid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This study measured the concentrations of ondansetron in plasma and cerebrospinal fluid (CSF) in six volunteers after oral dosing to steady state. Ondansetron concentrations ranged from 39.5–147 ng ml−1 in plasma and from 2.6–15.4 ng ml−1 in CSF. There was good correlation between plasma and CSF concentrations (r=0.89,p=0.017). CSF concentrations were less than 15% of plasma concentrations in all cases, indicating that the rate of penetration of the blood brain barrier by ondansetron is low.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02247730
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