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  • 1
    ISSN: 1432-0568
    Keywords: Neocortex ; Development ; 6-Hydroxydopamine ; Noradrenaline ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Newborn rats received an intracisternal injection of 6-hydroxydopamine (100 μg) within 16 h after birth. Treatment effects upon noradrenaline uptake (with or without desmethylimipramine pre-incubation), endogenous noradrenaline, dopamine, and serotonin were biochemically assayed. Noradrenaline uptake and endogenous noradrenaline content were permanently reduced to less than 5% of control values. Reduction of endogenous dopamine content was less marked: at day 60, values were about 40% of controls. Serotonin content remained unaffected. Cell density countings in postnatal day 15 temporal cortex revealed an about 16% reduction in layers II and III of treated animals. These modifications of cortical geometry were discussed with reference to measurements of cortical thickness and ultrastructural observations on postnatal days 2, 5 and 15. Both supranormal involution and growth processes might result from the neurotoxin treatment. Whereas some of the degeneration processes might be due to general cytotoxic effects, this is less likely for the supranormal growth processes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 14 (1971), S. 38-47 
    ISSN: 1432-1106
    Keywords: Neuroglia ; Migrations ; Optic Tract ; Quantitative radio-autography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Une étude radio-autographique quantitative des migrations névrogliques dans le tractus optique a été effectuée chez le Rat, après injection de thymidine tritiée, respectivement à 2 jours et demi et 6 jours après la naissance. Les paramètres suivants ont été analysés: densité de l'ensemble des cellules névrogliques; densité et pourcentage des cellules névrogliques marquées; nombre de grains par noyau, dans les trois segments du tractus; pourcentage respectif des cellules marquées dans les trois régions contiguës. Des résultats obtenus il ressort, entre autres, que la densité névroglique atteint son maximum au 9ème jour de la vie postnatale et qu'il existe d'importantes variations topographiques de cette densité et du taux des multiplications cellulaires. Ces observations permettent de discuter les conceptions actuelles sur la cinétique de la gliose de myélinisation, ainsi que divers problèmes concernant l'origine et la migration des nouvelles cellules névrogliques. Ce travail a été effectué grâce à l'aide financière du C.E.N. de Saclay, de l'I.N.S.E.R.M. et de la F.R.M.F. Les photographies ont été réalisées par P. Sibleyras. R. Georges a mis au net le manuscrit.
    Notes: Summary Following injection of tritiated thymidine at 21/2 and 6 days respectively after birth, a quantitative radio-autographic study has been made of the neuroglia migrations in the optic tract of the rat. The following parameters have been analysed: the density of the whole lot of the neuroglia cells, the density and percentage of the labelled neuroglia cells, the number of grains per nucleus in the three segments of the tract, the respective percentage of the labelled cells in the three contiguous areas. From the results we can conclude among other things that the neuroglia density reaches its maximum on the 9th day of the postnatal life and that important topographical variations of this density and of the rate of the cellular multiplications exist. These observations permit us to discuss the existing concepts of the kinetic of the myelination gliosis, as well as the various problems concerning the origin and the migration of the new neuroglia cells.
    Type of Medium: Electronic Resource
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