ISSN:
1573-2592
Keywords:
Mycobacterium avium (MA)
;
MA complex
;
AIDS
;
cytokines
;
interleukin-1 (IL-1)
;
IL-6
;
monocytes
;
tumor necrosis factor-α
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The pathophysiologic basis for the exuberant intracellular growth of Mycobacterium avium complex (MAC) in AIDS patients is unclear but may relate to altered expression of modulatory cytokines. Interleukin (IL)-1, IL-6, and TNF-α expression by monocytes from AIDS patients and healthy subjects (HS) stimulated with isogeneic MAC strains (SmT, smooth-transparent, virulent; SmD, smooth-domed, avirulent) was examined. Spontaneous cytokine production was not observed in patients with AIDS. MAC strains induced less IL-1α and IL-1β release in AIDS patients than HS (P 〈 0.05). The ratio of cell-associated to supernatant IL-1α also was increased in AIDS patients (P = 0.03). IL-1β mRNA expression paralleled protein release in either group of subjects. In both HS and AIDS patients, stimulation with SmD induced more IL-1 and TNF-α release by monocytes compared to SmT. In AIDS patients, SmD also induced greater IL-6 release than SmT (P 〈 0.01). Alterations in monocyte expression and compartmentalization of the regulatory cytokines IL-1 and IL-6 may enhance bacterial replication and contribute to the patho-genesis of MAC infection in AIDS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1027316324382
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