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  • Multiple trauma  (1)
  • Open access, Communication, Evidence based practice, Health services research, Intensive care, Patient-centred medicine  (1)
  • Open access, Communication, Health services research, Qualitative research  (1)
  • Open access, Epidemiology, Haematology (incl blood transfusion), Health policy, Intensive care, Public health, Research methods  (1)
Document type
Keywords
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Years
  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of I.V. labetalol for treatment of posttraumatic hyperdynamic state (1984)
    Springer
    Intensive care medicine 10 (1984), S. 133-137 
    Details
    ISSN: 1432-1238
    Keywords: Adrenoceptor blocking agents: labetalol ; Multiple trauma ; Hyperdynamic state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A hyperdynamic state, characterized by an elevated blood pressure and tachycardia is frequently seen during the first few days following severe multiple trauma. We examined the cardiovascular effects of the alpha and beta adrenoceptor blocking agent labetalol in patients presenting a hyperdynamic cardiovascular state some days after major trauma. Ten patients with a heart rate-systolic blood pressure product (RPP) of more than 2000 during 6 consecutive hours, despite normovolaemia, adequate ventilation, analgesia and sedation were investigated. After a mean dose of 2.1±1.2 mg·kg-1 (mean±SD) of labetalol injected intravenously over a 10-min period, heart rate decreased from 117±28 to 102±19 beats·min-1, systolic arterial pressure from 25±3.5 to 18.5±2.7 kPa, diastolic pressure from 11±1.7 to 9.5±1.7 kPa, mean arterial blood pressure from 15.5±2.1 to 12.4±2.1 kPa, and the RPP from 2880±867 to 1853±373. The beneficial effect of this dose lasted 24 h in 8 of 10 patients without additional administration. No important side effects such as cardiac arrhythmias, hypotension, or bronchospasm were noted. We conclude that labetalol used in fractional intravenous doses permits an adequate treatment of a “hypertension-tachycardia syndrome” in severely injured patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265802
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    Paper (German National Licenses)
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  • 2
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    Prospective cohort study protocol to describe the transfer of patients from intensive care units to hospital wards (2015)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2015-07-10
    Description: Introduction The transfer of patient care between the intensive care unit (ICU) and the hospital ward is associated with increased risk of medical error and adverse events. This study will describe patient transfer from ICU to hospital ward by documenting (1) patient, family and provider experiences related to ICU transfer, (2) communication between stakeholders involved in ICU transfer, (3) adverse events that follow ICU transfer and (4) opportunities to improve ICU to hospital ward transfer. Methods This is a mixed methods prospective observational study of ICU to hospital ward transfer practices in 10 ICUs across Canada. We will recruit 50 patients at each site (n=500) who are transferred from ICU to hospital ward, and distribute surveys to enrolled patients, family members, and healthcare providers (ICU and ward physicians and nurses) after patient transfer. A random sample of 6 consenting study participants (patients, family members, healthcare providers) from each study site (n=60) will be offered an opportunity to participate in interviews to further describe stakeholders’ experience with ICU to hospital ward transfer. We will abstract information from patient health records to identify clinical data and use of transfer tools, and identify adverse events that are related to the transfer. Ethics and Dissemination Research ethics board approval has been obtained at the coordinating study centre (UofC REB13-0021) and 5 study sites (UofA Pro00050646; UBC-PHC H14-01667; Sunnybrook 336-2014; QCH 14-07; Sherbrooke 14-172). Dissemination of the findings will provide a comprehensive description of transfer from ICU to hospital ward in Canada including the uptake of validated or local transfer tools, a conceptual framework of the experiences and needs of stakeholders in the ICU transfer process, a summary of adverse events experienced by patients after transfer from ICU to hospital ward, and opportunities to guide quality improvement efforts.
    Keywords: Open access, Communication, Evidence based practice, Health services research, Intensive care, Patient-centred medicine
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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    PAPER CURRENT
  • 3
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    Clinical effects of blood donor characteristics in transfusion recipients: protocol of a framework to study the blood donor-recipient continuum (2015)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2015-01-21
    Description: Introduction When used appropriately, transfusion of red blood cells (RBCs) is a necessary life-saving therapy. However, RBC transfusions have been associated with negative outcomes such as infection and organ damage. Seeking explanations for the beneficial and deleterious effects of RBC transfusions is necessary to ensure the safe and optimal use of this precious resource. This study will create a framework to analyse the influence of blood donor characteristics on recipient outcomes. Methods and analysis We will conduct a multisite, longitudinal cohort study using blood donor data routinely collected by Canadian Blood Services, and recipient data from health administrative databases. Our project will include a thorough validation of primary data, the linkage of various databases into one large longitudinal database, an in-depth epidemiological analysis and a careful interpretation and dissemination of the results to assist the decision-making process of clinicians, researchers and policymakers in transfusion medicine. Our primary donor characteristic will be age of blood donors and our secondary donor characteristics will be donor–recipient blood group compatibility and blood donor sex. Our primary recipient outcome will be a statistically appropriate survival analysis post-RBC transfusion up to a maximum of 8 years. Our secondary recipient outcomes will include 1-year, 2-year and 5-year mortality; hospital and intensive care unit length of stay; rehospitalisation; new cancer and cancer recurrence rate; infection rate; new occurrence of myocardial infarctions and need for haemodialysis. Ethics and dissemination Our results will help determine whether we need to tailor transfusion based on donor characteristics, and perhaps this will improve patient outcome. Our results will be customised to target the different stakeholders involved with blood transfusions and will include presentations, peer-reviewed publications and the use of the dissemination network of blood supply organisations. We obtained approval from the Research Ethics boards and privacy offices of all involved institutions.
    Keywords: Open access, Epidemiology, Haematology (incl blood transfusion), Health policy, Intensive care, Public health, Research methods
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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    PAPER CURRENT
  • 4
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    Print and online newspaper coverage of the link between HPV and oral cancer in the UK: a mixed-methods study (2016)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2016-02-28
    Description: Objectives The role of human papillomavirus (HPV) in some oral cancers has been reported in the news press, though little is known about the content of these articles. This study aimed to examine how frequently the link between HPV and oral cancer has been reported in the news press and to examine the content of these articles. Design UK media articles were searched for articles relating to oral cancer and HPV in the database NexisUK. Of 854 articles identified by the initial search, 112 were eligible for inclusion (2002–2014) and content analysis was used to determine the main themes discussed. Results Themes included actor Michael Douglas’ claim that his throat cancer was caused by HPV, the riskiness of oral sex, health information (including HPV as a cause of oral cancer) and the need to vaccinate boys against HPV. Many articles also referred to the link between HPV and cervical cancer and the increasing incidence of HPV-related oral cancer. The largest peak in articles occurred when Michael Douglas discussed his cancer (June 2013). Facts about HPV and references to research were provided in some articles. Conclusions The link between HPV and oral cancer and the transmission of HPV via oral sex was regularly discussed, yet coverage often lacked detailed health information. This could increase awareness of the link between oral sex and HPV risk, but may also lead to public concern about oral sex as a sexual behaviour.
    Keywords: Open access, Communication, Health services research, Qualitative research
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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    PAPER CURRENT
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