ISSN:
1432-1432
Keywords:
Multiple protein sequence consensus
;
Alignment
;
Evolutionary tree
;
Clustering
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary A method for the alignment of two or more biological sequences is described. The method is a direct extension of the method of Taylor (1987) incorporating a consensus sequence approach and allows considerable freedom in the control of the clustering of the sequences. At one extreme this is equivalent to the earlier method (Taylor 1987), whereas at the other, the clustering approaches the binary method of Feng and Doolittle (1987). Such freedom allows the program to be adapted to particular problems, which has the important advantage of resulting in considerable savings in computer time, allowing very large problems to be tackled. Besides a detailed analysis of the alignment of the cytochrome c superfamily, the clustering and alignment of the PIR sequence data bank (3500 sequences approx.) is described.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02143508
Permalink
