ISSN:
1432-1246
Keywords:
Cadmium
;
Kidney
;
Metallothionein
;
Occupational exposure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In a 61-year-old woman, who had been exposed for 20 years to cadmium in the production of Ni-Cd batteries, nephrectomy of the contracted kidney was performed. The removed kidney was examined histologically and the cadmium concentration was determined in the cortex (44.97 μg g−1) and in the medulla (7.71 μg g−1). The homogenates of the renal cortex and medulla were subjected to gel filtration on Sephadex G-75. In the cortex, as well as the medulla, cadmium was predominantly found in the low-molecular (metallothionein) fraction, but in the cortex, Cd content in this fraction was six times higher than in the medulla. The determination of SH groups and proteins in high- and low-molecular fractions indicates an induction of the metallothionein formation primarily in the renal cortex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00383756
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