ISSN:
1040-0397
Keywords:
Oxygen
;
Permeability
;
Membrane
;
Skin
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The mammalian stratum corneum is a thin, highly organized polymeric membrane which is relatively impermeable to water but permeable to some gases including oxygen. Isolated stratum corneum membranes from perinatal Sprague-Dawley rats were mounted under electrodes used to determine the rate of diffusion of oxygen through the membrane. These membranes were consistently found to be permeable to oxygen, which could be quantitatively determined at a gold electrode at -0.6 V (vs. a Ag/AgCl electrode). The stratum corneum membrane was found to be anisotropic, with greater oxygen permeability when the gas diffused toward the electrolyte from the side of the membrane which would be oriented toward the exterior of the animal than when it diffused in the opposite direction. There is also evidence of anatomic site heterogeneity in the permeability of the membranes.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140050803
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