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  • 1
    Electronic Resource
    Electronic Resource
    Serum levels of soluble Fas/APO-1 receptor are increased in systemic sclerosis (1998)
    Springer
    Archives of dermatological research 290 (1998), S. 187-190 
    Details
    ISSN: 1432-069X
    Keywords: Key words Systemic sclerosis ; CD95 ; sFas ; Autoimmune disease ; Apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been suggested that rheumatic diseases may result from a deficit in Fas-mediated T-cell apoptosis. Recent studies have demonstrated increased soluble Fas in sera from lupus erythematosus patients. We were interested to determine whether elevated soluble Fas levels are associated with systemic sclerosis. Soluble Fas levels were retrospectively assayed using a sandwich enzyme-linked immunosorbent assay in serum from 30 patients with systemic sclerosis and 15 normal controls. Hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. Soluble Fas levels were analysed in subsets of patients with limited (lcSSc) versus diffuse cutaneous systemic sclerosis (dcSSc) and correlated with inflammatory activity. In systemic sclerosis soluble Fas serum levels (lcSSc, 2.19 ± 0.71 ng/ml, dcSSc 2.53 ± 1.37 ng/ml) were significantly higher than in normal controls (1.26 ± 0.36 ng/ml). However, there were no significant differences in soluble Fas levels between lcSSc and dcSSc and poor correlation between soluble Fas levels and inflammatory activity status. Detection of elevated soluble Fas might serve as a clinical marker for immunological dysregulation in systemic sclerosis, but not for inflammatory disease activity .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050288
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  • 2
    Electronic Resource
    Electronic Resource
    Mikrochimerismus Neuer Denkansatz für die Pathogenese der systemischen Sklerodermie (2000)
    Springer
    Der Hautarzt 51 (2000), S. 59-62 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Systemische Sklerodermie ; Graft-versus-Host-Erkrankung ; Mikrochimerismus ; Key words Systemic sclerosis ; Graft-versus-host-disease ; Microchimerism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Persistent cellular microchimerism might play a role in the pathogenesis of systemic sclerosis (SSc). Microchimerism results from the traffic of fetal cells through the placenta during pregnancy into the maternal circulation and their survival due to HLA class II compatibility. In female SSc patients the presence of fetal CD3-positive T-cells in the maternal circulation and of fetal cells in the affected skin tissue has been identified through y chromosome specific DNA sequences. The persistent microchimerism might cause SSc in certain patients by initiating a fetal anti-maternal Graft-versus-host-like response.
    Notes: Zusammenfassung Ein persistierender zellulärer Mikrochimerismus könnte in der Pathogenese der systemischen Sklerodermie (SSc) eine Rolle spielen. Der Mikrochimerismus entsteht durch den Transport fetaler Zellen durch die Plazenta während der Schwangerschaft in die maternale Zirkulation und deren Überleben aufgrund einer weitgehenden HLA-Klasse-II-Kompatibilität. Bei weiblichen SSc-Patienten wurde die Anwesenheit von fetalen CD3-positiven T-Zellen in der maternalen Zirkulation und von fetalen Zellen im befallenen Hautgewebe in Form von Y-Chromosomen-spezifischen DNA-Sequenzen nachgewiesen. Der persistierende Mikrochimerismus könnte bei bestimmten Patienten über eine fetoantimaternale Graft-versus-Host-ähnliche Reaktion eine SSc auslösen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050012
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    Paper (German National Licenses)
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