ISSN:
1432-2277
Keywords:
Key words Hepatocellular carcinoma
;
Liver transplantation
;
Liver surgery
;
Transarterial chemoembolization
;
Percutaneous ethanol injection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Between January 1989 and June 1997, 533 patients (423 male, 110 female, mean age 61 years, range 22–89 years) with hepatocellular carcinoma (HCC) were observed at our center. We report on 419 patients retrospectively compared for different treatments: liver transplantation (LT; 55 patients), resective surgery (RS; 41 patients), transarterial chemoembolization (TACE; 171 patients) and percutaneous ethanol injection (PEI; 152 patients). The 3- and 5-year actuarial survival rates were, respectively, 72 % and 68 % for LT, 64 and 44 % for RS, 54 and 36 % for PEI, and 32 and 22 % for TACE. Survival curves were compared for sex, age, tumor characteristics, alphafetoprotein level, Child class, and etiology of cirrhosis. All patient-related characteristics examined (sex, age) are not significantly related to patient survival. Tumor-related variables and associated liver disease variables significantly conditioned survival in relation to different treatments. LT seems to be the treatment of choice for monofocal HCC less then 5 cm in diameter and in selected cases of plurifocal HCC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050459
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