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  • Key words Exenterative surgery • Urinary diversion • Gynecological tumors  (1)
  • Mouse (BALB/c)  (1)
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  • 1
    ISSN: 1433-0563
    Keywords: Key words Exenterative surgery • Urinary diversion • Gynecological tumors ; Schlüsselwörter Exenteration • Harnableitung • ; Gynäkologische Tumoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei fortgeschrittenen oder rezidivierenden Tumorerkrankungen der weiblichen Genitalorgane ist die pelvine exenterative Resektion dann anzustreben, wenn eine lokale Tumorinfiltration des unteren Harntraktes vorhanden ist und wenn eine Strahlentherapie mit kurativer Zielsetzung als Alternative nicht mehr zur Verfügung steht. Bei der Planung des operativen Vorgehens muß die Resektion und Rekonstruktion der betroffenen ableitenden Harnorgane mit in das gynäkologische Therapiekonzept einbezogen werden. In der vorliegenden Serie war bei 11/32 Patientinnen die Rekonstruktion der ableitenden Harnwege möglich, so daß die Harnblase mit ausreichender Funktion erhalten werden konnte. Zur Harnableitung nach vorderer Exenteration wurde bei 17/32 Patientinnen ein kontinentes Harnreservoir gewählt und bei 4/17 Patientinnen ein Ileumkonduit. Nur bei Anlage eines kontinenten Harnreservoirs war aufgrund von Komplikationen in 5 Fällen eine operative Reintervention erforderlich. Bei diesen Patientinnen bestand ein Zustand nach primärer Strahlentherapie des gynäkologischen Tumors. Bei weiteren 11 Patientinnen nach einer primären Strahlentherapie traten keine Komplikationen auf. 9 der 32 Patientinnen haben den operativen Eingriff mit einer durchschnittlichen Überlebenszeit von 40,8 (25–57) Monaten bislang tumorfrei überlebt. Kontinente Harnreservoire stellen im Rahmen einer pelvinen exenterativen Maßnahme eine exzellente Möglichkeit dar, den damit verbundenen Ausfall an Körperfunktionen zu ersetzen. Aufgrund der häufig sehr komplexen Verhältnisse v. a. infolge vorausgegangener umfangreicher therapeutischer Maßnahmen ist aber eine strenge Selektion der Patientinnen unverzichtbare Voraussetzung.
    Notes: Summary In locally advanced or recurrent tumors of the female genital tract anterior or total exenteration may be mandatory in case of tumor invasion into the lower urinary tract or if a second course of radiation therapy is not feasible. The management of resection and reconstruction of the affected lower urinary tract has to be well integrated into the gynecological therapeutic concept. In 11/32 patients the reconstruction of the partially resected lower urinary tract was feasible with preservation of a functionally intact urinary bladder. Urinary diversion following pelvic exenteration was achieved in 13/17 patients with a continent urinary reservoir and in 4/17 patients with an ileal conduit. Operative reinterventions were needed only in patients with continent urinary diversion in 5 cases. All these patients had a past history of primary radiation therapy of their gynecological tumor. In the remaining other 11 patients with a history of primary radiation therapy no complications occurred. 9 of 32 patients survived the operative procedure 40,8 (25–57) month with no evidence of recurrent tumor. Continent urinary diversion represents an excellent therapeutic option for replacement of function lost due to exenterative pelvic surgery. Stringent selection of patients is mandatory to consider the presented therapeutic concept a reasonable tool in the management of the described clinical situations.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 292 (1998), S. 275-282 
    ISSN: 1432-0878
    Keywords: Key words Interstitial cells (Cajal) ; Large intestine ; Fluorescent dyes ; Vital staining ; Ultrastructure ; Mouse (BALB/c)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Interstitial cells of Cajal (ICCs) are believed to be a major element in generating the spontaneous rhythm of the gastrointestinal tract. A prominent problem in the study of these cells has been the difficulty in observing them in intact tissues. We used the lipophilic dye DiI to stain ICCs in the submucosal-circular muscle border of freshly dissected mouse colon. The placement of small DiI crystals in this area resulted in the labeling of ICC-like cells. Two main morphological cell types, viz., bipolar and multipolar, were noted. Bipolar cells had two primary processes emerging from the poles of an elongated soma. The mean length of these processes was 78.7 μm. These cells constituted 42.3% of the sample (n=105). Multipolar cells (54.3% of total) had a less elongated soma and extended 3–6 main processes whose mean length was 56.3 μm. These processes showed no preferred direction. The length of the primary processes of bipolar cells was 40% greater than that of multipolar cells (P〈0.02). Three cells (2.9%) had only one primary process. The DiI stain could be converted into a stable electron-opaque product. Electron-microscopic observations showed that these cells had the typical appearance of ICCs reported in previous studies. This staining method should be useful for physiological investigations of ICCs in gastrointestinal tissues.
    Type of Medium: Electronic Resource
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