ISSN:
1432-0843
Keywords:
Key words Hematopoietic growth factor
;
Lung cancer
;
Chemotherapy
;
Neutropenia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A prospective randomized study was conducted to determine the optimal schedule of rhG-CSF (recombinant human granulocyte colony-stimulating factor). A group of 33 lung cancer patients treated with MVP therapy (mitomycin, vindesine, and cisplatin) were randomly assigned to three groups: an early prophylaxis group in which rhG-CSF was initiated on day 2 of the MVP cycle; a late prophylaxis group in which rhG-CSF was initiated on day 8; and a therapeutic group in which rhG-CFS was initiated after the onset of neutropenia. Ten patients who had received MVP therapy without rhG-CSF were also analyzed as a no-support group. The incidence of neutropenia was 80% (16/20 courses) in the early prophylaxis group, 44% (8/18) in the late prophylaxis group, 94% (17/18) in the therapeutic group, and 94% (16/17) in the no-support group. The incidence of neutropenia in the late prophylaxis group was less than in the early prophylaxis group (P〈0.05), the therapeutic group (P〈0.01), and the no-support group (P〈0.01). The late prophylactic rhG-CSF schedule was therefore more effective in countering neutropenia than either the early prophylactic or therapeutic schedule.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002800050440
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