ISSN:
1432-2072
Keywords:
Amphetamine
;
Ascorbate
;
Haloperidol
;
Intraventricular infusion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The behavioral response to amphetamine was monitored in rats that received simultaneous intraventricular infusions of saline or ascorbate. Both groups of animals displayed comparable responses, although ascorbate significantly delayed the onset of amphetamine-induced locomotion and rearing. In rats pretreated with a threshold dose of haloperidol (0.025 mg/kg), virtually all aspects of the amphetamine response were attenuated, and this effect was enhanced by ascorbate. In haloperidol-pretreated rats, ascorbate significantly lowered sniffing and forepaw shuffling throughout the amphetamine response. These results suggest that ascorbate antagonizes dopaminergic transmission by a central mechanism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00176860
Permalink
