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  • 1
    Electronic Resource
    Electronic Resource
    Antiproliferative effect of heparin on human smooth muscle cells cultured from intimal hyperplastic lesions of vein grafts (1992)
    Springer
    Annals of vascular surgery 6 (1992), S. 265-271 
    Details
    ISSN: 1615-5947
    Keywords: Intimal hyperplasia ; heparin ; smooth muscle cells ; saphenous vein grafts ; antiproliferative effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antiproliferative effect of heparin on cultured smooth muscle cells in proliferating human smooth muscle cells derived from clinical lesions of intimal hyperplasia was tested. Smooth muscle cells were obtained from stenotic segments excised from failing in situ saphenous vein bypass grafts in three patients. The nonadventitial portion of the excised tissue was explanted into cell culture using standard techniques without the addition of exogenous growth factors. Under these conditions, rapid cell outgrowth was observed from these explants, in contrast to minimal growth of smooth muscle cells from normal veins from the same patients. Immunohistochemical staining with antiactin antibody confirmed that the cells cultured from the stenotic lesions were smooth muscle cells. Incubation of these cells with porcine mucosal heparin revealed a significant (p〈.01) dose-dependent inhibition of cell proliferation as measured by radioactive thymidine incorporation. Mean inhibition of six subcultures tested ranged from 3 to 46%, at heparin concentrations of 1 to 1,000µg/ml. The magnitude of heparin's antiproliferative effect varied among the cell lines from different patients, but 10–30% inhibition was consistently observed at heparin concentrations usually attained in vivo. The maximal inhibition achieved was 65% in one cell line at the highest heparin dose. We conclude that heparin exerts a significant antiproliferative effect on human smooth muscle cells cultured from intimal hyperplastic lesions from in situ saphenous vein bypass grafts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02000273
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  • 2
    Electronic Resource
    Electronic Resource
    Formation and homolytic cleavage of the Ni(II)-styryl σ-bond (1973)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 11 (1973), S. 1953-1960 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A Ni-carbon σ-bond is formed from biscyclooctadienenickel(0) and styrene in the presence of organic acids. Homolytic cleavage of this bond gives free radicals. The mechanism of formation and disappearance of the radical-supplying species is deduced from kinetic and other data. A competing coordinated ligand insertion reaction is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1973.170110816
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  • 3
    Electronic Resource
    Electronic Resource
    Polymers of tertiary amines (1972)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 10 (1972), S. 625-633 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Polymers of tertiary amines and their hydrochlorides of molecular weights in the range 300-2000 have been prepared, starting from trans-1,4-dichlorobutene-2, and primary amines. The polymers present interesting solubility properties. Variation of the reaction conditions leads to crosslinked insoluble polymers. Reaction of the soluble tertiary amine polymers with organic acid dichlorides leads to polymers of tertiary amine-amides, a new type of polymer.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1972.150100226
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