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Regulation of AID, the B-cell genome mutator [Reviews] (2013)

Keim, C., Kazadi, D., Rothschild, G., Basu, U.

Cold Spring Harbor Laboratory Press

In: Genes & Development

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Publication Date: 2013-01-11

Description: The mechanisms by which B cells somatically engineer their genomes to generate the vast diversity of antibodies required to challenge the nearly infinite number of antigens that immune systems encounter are of tremendous clinical and academic interest. The DNA cytidine deaminase activation-induced deaminase (AID) catalyzes two of these mechanisms: class switch recombination (CSR) and somatic hypermutation (SHM). Recent discoveries indicate a significant promiscuous targeting of this B-cell mutator enzyme genome-wide. Here we discuss the various regulatory elements that control AID activity and prevent AID from inducing genomic instability and thereby initiating oncogenesis.

Keywords: Immunology

Print ISSN: 0890-9369

Topics: Biology

Published by Cold Spring Harbor Laboratory Press

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