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  • Hochschulschrift  (2)
  • Tumor immunotherapy  (2)
Document type
Keywords
Publisher
Language
Years
  • 1
    Book
    Book
    Zur Paläoozeanographie hoher Breiten : Stellvertreterdaten aus Foraminiferen = Foraminiferal proxies (1997)
    Bremerhaven : Alfred-Wegener-Institut für Polar- und Meeresforschung
    Details Availability
    Keywords: Hochschulschrift ; Forschungsbericht ; Foraminiferen ; Paläoozeanographie ; Biogeochemie ; Foraminiferen ; Paläoozeanographie ; Biogeochemie
    Type of Medium: Book
    Pages: III, 146 S. , graph. Darst., Kt.
    Series Statement: Berichte zur Polarforschung 243
    URL: https://www.gbv.de/dms/tib-ub-hannover/235641057.pdf
    RVK:
    WI 4410
    RVK:
    TI 7200
    Language: German
    Note: Literatur S. 128 - 145 , Intermediärsprache: Englisch , Zugl.: Bremen, Univ., Habil.-Schr., 1996
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  • 2
    Book
    Book
    Verbreitung und Umwelt benthischer Foraminiferen in der Norwegischen See (1985)
    Details Availability
    Keywords: Hochschulschrift
    Type of Medium: Book
    Pages: II, 126 S., 2 Tf , Ill., graph. Darst., Kt
    Language: German
    Note: Kiel, Univ., Diss., 1985
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  • 3
    Electronic Resource
    Electronic Resource
    Homing of intravenously and intralymphatically injected human dendritic cells generated in vitro from CD34+ hematopoietic progenitor cells (1999)
    Springer
    Cancer immunology immunotherapy 48 (1999), S. 118-122 
    Details
    ISSN: 1432-0851
    Keywords: Key words Dendritic cells ; Tumor immunotherapy ; Homing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dendritic cells (DC) are professional antigen-presenting cells that can be generated in vitro from CD34+ peripheral blood progenitor cells by recombinant cytokines. These cells have potential implications for immunotherapeutic approaches in the treatment of cancer and other diseases. Physiologically, immature DC in the periphery capture and process antigens, then mature to interdigitating DC and migrate to lymphoid organs, where they activate lymphocytes. However, it is not known if DC generated in vitro have the capacity to traffic in vivo to the lymphoid tissues, such as spleen and lymph nodes. We have investigated whether human radiolabeled DC differentiated in vitro migrate and localize to lymphoid tissues after intravenous and intralymphatic injection. The distribution and localization of the DC were evaluated in five patients with malignant melanoma using serial whole-body gamma camera imaging. Intravenously infused DC demonstrated transient lung uptake followed by localization in the spleen and liver for at least 7 days. DC injected into a lymphatic vessel at the dorsal foot were rapidly detected in the draining lymph nodes where they remained for more than 24 h. These data suggest that DC differentiated in vitro localize preferentially to lymphoid tissue, where they could induce specific immune responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050555
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  • 4
    Electronic Resource
    Electronic Resource
    Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells (2000)
    Springer
    Cancer immunology immunotherapy 49 (2000), S. 152-156 
    Details
    ISSN: 1432-0851
    Keywords: Key words Dendritic cells ; Tumor immunotherapy ; Vaccination ; Anaphylactic reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dendritic cells are professional antigen-presenting cells that can be generated in vitro either from monocytes or from CD34+ peripheral blood progenitor cells by using recombinant cytokines. These cells have potential implications for immunotherapeutic approaches in the treatment of cancer and other diseases. We have conducted a phase I study in melanoma patients using peptide-pulsed dendritic cells cultured in medium supplemented with 10% fetal calf serum (FCS) and a cocktail of cytokines. Peptide-pulsed dendritic cells were injected intravenously at 2-week intervals. Here we report on a case of type I hypersensitivity anaphylactic reaction after repetitive vaccination with autologous peptide-pulsed cells. Pre-vaccination and post-vaccination serum samples were evaluated for the presence of antibodies to FCS and bovine serum albumin (BSA). A retrospective study in 7 patients vaccinated with FCS-cultured dendritic cells demonstrated the presence of IgG and IgM antibodies to FCS and BSA after vaccination in 6 out of 7 patients. However, IgE antibodies were absent in all patients with the exception of the patient developing anaphylaxis. The patient's serum was demonstrated to contain a strong IgE response directed against BSA. In contrast, 2 patients vaccinated with dendritic cells cultured under serum-free conditions developed no antibodies to FCS and BSA after repetitive vaccination. We suggest that patients can be sensitized with an IgE response against BSA leading to anaphylactic reactions. On the basis of these data, dendritic cells cultured in autologous serum or under serum-free conditions are recommended for therapeutic applications in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050614
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