ISSN:
1432-2277
Keywords:
CMV, kidney transplantation, HLA-DR7
;
CMV, kidney transplantation, triple therapy
;
Kidney transplantation, CMV, HLA-DR7
;
HLA-DR7, CMV, kidney transplantation
;
Triple therapy, kidney transplantation, CMV
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In a prospective study, an analysis of risk factors for the development of cytomegalovirus (CMV) infection and disease was performed on 77 renal allograft recipients. Twenty-five out of the 77 recipients (32%) had a CMV infection. Twenty-two of the recipients received triple immunosuppressive therapy (cyclosporin A, prednisolone, and azathioprine) while the remaining 55 received standard therapy (cyclosporin A and prednisolone). In 23 recipients (30%) acute rejection was diagnosed and the first positive parameter of infection occurred 22 days after rejection therapy. Infection occurred in 10 out of 18 HLA-DR7-positive recipients (56%) and in 15 out of 59 HLA-DR7-negative recipients (25%; P〈 0.02). In multiple regression analysis, HLA-DR7 was found to be a significant predictor of CMV infection (P〈 0.005). CMV disease was diagnosed in only 9 out of 25 recipients with an acute infection. Six recipients (67%) with CMV disease received triple therapy for maintenance immuuosuppression; this was significantly correlated to CMV disease (P〈 0.05) as compared to three recipients (33%) with CMV disease maintained with standard therapy. Our data suggest that HLA-DR7-positive recipients are more susceptible to CMV infection and that CMV disease is associated with triple immunosuppressive therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00336713
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